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Closamectin Injection Cattle

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Closamectin Injection Cattle

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Closamectin treats mixed trematode (liver fluke) and nematode or arthropod infestations due to gastrointestinal roundworms, lungworms, eyeworms, warbles, mites and lice of cattle.


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Closamectin treats mixed trematode (liver fluke) and nematode or arthropod infestations due to gastrointestinal roundworms, lungworms, eyeworms, warbles, mites and lice of cattle.

Closamectin Injection is a ready-to-use solution, containing:
Ivermectin 0.5% w/v
Closantel 12.5% w/v


One dose of Closamectin Injection effectively controls internal and external parasites that impair the health and productivity of cattle.

For the treatment of mixed trematode (fluke) and nematode or arthropod infestations due to gastrointestinal roundworms, lungworms, eyeworms, warbles, mites and lice of cattle.

Gastrointestinal roundworms: Ostertagia ostertagi (including inhibited larval stages), Ostertagia lyrata (adult), Haemonchus placei (adult and immature), Trichostrongylus axei (adult and immature), Trichostrongylus colubriformis (adult and immature), Cooperia oncophora (adult and immature), Cooperia punctata (adult and immature), Cooperia pectinata (adult and immature), Oesophagostomum radiatum (adult and immature), Nematodirus helvetianus (adult), Nematodirus spathiger (adult), Strongyloides papillosus (adult), Bunostomum phlebotomum (adult and immature), Toxocara vitulorum (adult), Trichuris spp.

Lungworms: Dictyocaulus viviparus (adult and 4th stage larvae)

Liver Fluke (trematodes): Fasciola gigantica, Fasciola hepatica. Treatment of fluke at 12 weeks (mature)>99% efficacy. Treatment of fluke from 7 weeks (late immature) >90% efficacy.

Eyeworms (adult): Thelazia spp.

Cattle grubs (parasitic stages): Hypoderma bovis, Hypoderma lineatum

Lice: Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus

Mange Mites: Psoroptes ovis (syn P communis var bovis), Sarcoptes scabiei var bovis

Closamectin Injection may also be used as an aid in the control of the biting louse Damalinia bovis and the mange mite Chorioptes bovis, but complete elimination may not occur.

Dosage & Administration

Bodyweight and dosage should be accurately determined prior to treatment to avoid underdosing.

Closamectin Injection should be administered at a dosage rate of 200 mcg ivermectin per kg and 5mg closantel per kg bodyweight. It should be injected subcutaneously in the middle portion of the neck using the aseptic technique. A maximum volume of 10ml should be administered at any one site with any residual volume administered at another site in the neck. The first dose should be injected in the right neck with any residual volumes injected into separate sites on the left and right neck. A sterile 16-gauge, one-inch needle is recommended. Use of a draw-off needle is recommended to avoid excess broaching of the stopper.

Withdrawal Period

Animals must not be slaughtered for human consumption during treatment. Cattle must not be slaughtered within 49 days of treatment for human consumption. Do not use in cattle producing milk for human consumption. Do not use in non-lactating dairy cows including pregnant heifers within 60 days of calving. Do not use any closantel-containing products during the 49 day withdrawal period. If an additional ivermectin-only product is administered within the 49 day withdrawal period set for Closamectin Injection, care should be taken to observe the longest overall withdrawal period.

Contraindictions, Warnings etc

Do not use in cases of known hypersensitivity to the active ingredients.

This product is not for intravenous or intramuscular use. Do not smoke, eat or drink while handling the product. Direct contact of the product with the skin should be kept to a minimum. Wash hands after use. Take care to avoid selfinjection. Inadvertent self-injection may result in local irritation and/or pain at the injection site.

Avermectins may not be well tolerated in all non target species (cases of intolerance with fatal outcome are reported in dogs – especially Collies, Old English Sheepdogs and related breeds or crosses, and also in turtles/tortoises). Transitory discomfort has been observed in some cattle following subcutaneous administration. Tissue swellings at the injection site are common up to 48 hours after injection which resolve thereafter without treatment. Hardness on palpation may be observed up to 7 days following administration. These reactions resolve without treatment.

To avoid secondary reactions due to the death of Hypoderma larvae in the oesophagus or in the spine it is recommended to administer the product at the end of warble fly activity and before the larvae reach their resting sites. Consult your veterinarian on the correct timing of treatment.

Overdose: Closantel like other salicylanilides is a potent uncoupler of oxidative phosphorylation and the safety index is not as high as is the case of many other anthelmintics. However where used as directed there are unlikely to be any untoward effects. Signs of overdosage can include slight loss of appetite, loose faeces, decreased vision and increased frequency of defecation. High doses may cause blindness, hyperventilation, general weakness and inco-ordination,
hyperthermia, convulsions, tachycardia and in extreme cases death. Treatment of overdosage is symptomatic as no antidote has been identified.

Pharmaceutical Precautions

Do not contaminate surface water or ditches with the product or used container. Any unused product or waste materials should be disposed off in accordance with national requirements.

Do not store above 25?C. Protect from light. This product does not contain a preservative. After first dose discard the vial within 28 days. This date should be recorded on the label. Discard unused material.

Further Information

Ivermectin belongs to the avermectin [3-AV] class of anthelmintics in the endectocides. Chemical group of anthelmintic endectocides [3-AV]. Closantel is a member of the salicylanilide class of anthelmintics.

Further information for the treatment programmes for mixed infestations consisting of nematodes and/or ectoparasite concurrent with fluke.
The timing for treatment should be based on epidemiological factors and should be customised for each individual farm. As with other anthelmintics, veterinary
advice should be sought on appropriate dosing programme and stock management to achieve adequate parasite control and reduce the likelihood of resistance developing.

Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:

Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
Underdosing which may be due to underestimation of bodyweight, misadministration of the product, or lack of calibration of the dosing device.

Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the tests strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.

Resistance to ivermectin has been reported in Cooperia spp in cattle. Therefore the use of this product should be based on local epidemiological information about the susceptibility of the Cooperia spp and recommendations on how to limit further selection for resistance to anthelmintics.

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Closamectin Injection Cattle

Closamectin Injection Cattle

Closamectin treats mixed trematode (liver fluke) and nematode or arthropod infestations due to gastrointestinal roundworms, lungworms, eyeworms, warbles, mites and lice of cattle.